Fetal MRI

Fetal CT
Dr Pascale Sonigo
3D/4D ultrasound
  • Radiologist (M.D.)
  • Pediatric Radiology and Fetal Imaging
  • Ultrasound, Fetal MRI, Fetal CT
Dr Pascale SonigoDr Pascale Sonigo


Dr Pascale Sonigo
- Doctorate in Medicine (Ph.D.) - Specialty: Radio diagnostic and Medical Imaging
- Former specialized intern in medicine at the Rouen Hospital Group de Rouen
- Former Head Clinical Assistant at the Parisian Hospital Group (2nd university and hospital level)
- Consulting Practitioner for the Parisian Hospital System (APHP Paris)
- Member of the International Society of Ultrasound in Obstetrics and Gynecology.
- Member of the Radiological Society of North America (RSNA)
- Member of the French College for fetal echography
- Member of the French Radiology Society.
- Member of the Multidisciplinary Center for Prenatal Diagnostics at the NECKER hospital (an accredited center)

Course of Study / Degrees

Course of Study


Medical School at the Necker Children’s Hospital (Paris 5th arrondissement)


Specialty Internship, medical track, DRASS Ile de France and DRASS Haute Normandie


Necker Children’s Hospital, Paris, Pediatric Radiology
Head Clinical Assistant, Service of Prof. LALLEMAND


Necker Children’s Hospital, Paris Pediatric Radiology
First Assistant, Service of Prof. BRUNELLE



Doctorate Thesis in Advanced Medicine
Validation of diploma of specialized studies


University diploma in Medical Echography and Ultrasonic methods
Paris University (5th arrondissement).

University diploma in Maxillofacial Radiology
CHU Bicêtre. Pr. Doyon

University diploma in Magnetic Resonance ImagingCHU Bicêtre. Pr. Doyon

University diploma in fetal medicine
CHU Necker. Pr. Dumez
Dissertation: "Magnetic Resonance Imaging in the evaluation of fetal malformations "


Dr Pascale SonigoRefining the prognosis of fetuses infected with Cytomegalovirus in the first trimester of pregnancy by serial prenatal assessment: a single-centre retrospective study.

Faure-Bardon V, Millischer AE, Deloison B, Sonigo P, Grévent D, Salomon L, Stirnemann J, Nicloux M, Magny JF, Leruez-Ville M, Ville Y.
BJOG. 2020 Feb\127(3):355-362. doi: 10.1111/1471-0528.15935. Epub 2019 Oct 15.PMID: 31505103.

Glial Periorbital Heterotopia: A Rare Type of Ocular Mass.

di Pasquo E, Kuleva M, Sonigo P, Millischer AE, Bremond-Gignac D, Ville Y, Salomon LJ.
J Ultrasound Med. 2020 Aug39(8):1491-1496. doi: 10.1002/jum.15249. Epub 2020 Mar 2.PMID: 32118307.

Heterogeneity in defining fetal callosal pathology: a systematic review.

Mahallati H, Sotiriadis A, Celestin C, Millischer AE, Sonigo P, Grevent D, O'Gorman N, Bahi-Buisson N, Attié-Bitach T, Ville Y, Salomon LJ.
Ultrasound Obstet Gynecol. 2020 Aug 15. doi: 10.1002/uog.22179. Online ahead of print.PMID: 32798278.

Prenatal imaging patterns of different forms of infantile myofibromatosis.

Fraissenon A, Benchimol G, Cabet S, Brasseur-Daudruy M, Sonigo P, Salomon LJ, Guibaud L.
Ultrasound Obstet Gynecol. 2020 Nov56(5):782-784. doi: 10.1002/uog.21964.PMID: 31909539.

Retroperitoneal Approach for Ureteropelvic Junction Obstruction: Encouraging Preliminary Results With Robot-Assisted Laparoscopic Repair.

Blanc T, Kohaut J, Elie C, Clermidi P, Pio L, Harte C, Bronnimann E, Botto N, Rousseau V, Sonigo P, Vaessen C, Lottmann H, Aigrain Y.
Front Pediatr. 2019 May 287:209. doi: 10.3389/fped.2019.00209. eCollection 2019.PMID: 31192176.

Biometric and morphological features of the fetal bladder in lower urinary tract obstruction on magnetic resonance imaging: new perspectives for fetal cystoscopy

Vinit N, Grevent D, Millischer-Bellaiche AE, Pandya VM, Sonigo P, Delmonte A, Sarnacki S, Aigrain Y, Boddaert N, Bessieres B, Benchimol G, Salomon LJ, Stirnemann JJ, Blanc T, Ville Y.
Ultrasound Obstet Gynecol. 2019 Apr 22. doi: 10.1002/uog.20297..

Non-visualization of fetal gallbladder (NVFGB) by ultrasound in second trimester of pregnancy: a systematic review of the literature on postnatal outcome

di Pasquo E, Kuleva M, Rousseau A, Vitucci A, Sonigo P, Chardot C, Salomon LJ, Ville Y
Ultrasound Obstet Gynecol. 2019 Feb 27. doi: 10.1002/uog.20252.

Fetal MRI findings in a retrospective cohort of 26 cases of prenatally diagnosed CHARGE syndrome individuals

Millischer AE, Sonigo P, Attie T, Spaggiari E, O'Gorman N, Bessieres B, Kermorvant E, Boddaert N, Salomon LJ, Grevent D.
Prenat Diagn. 2019 Feb 4. doi: 10.1002/pd.5429. .

Prenatally diagnosed periventricular nodular heterotopia: Further delineation of the imaging phenotype and outcome.

Deloison B, Sonigo P, Millischer-Bellaiche AE, Quibel T, Cavallin M, Benoist G, Quelin C, Jouk PS, Lev D, Alison M, Baumann C, Beldjord C, Razavi F, Bessires B, Boddaert N, Ville Y, Salomon LJ, Bahi-Buisson N.
Eur J Med Genet. 2018 Dec.

A neuropathological study of novel RTTN gene mutations causing a familial microcephaly with simplified gyral pattern.

Chartier S, Alby C, Boutaud L, Thomas S, Elkhartoufi N, Martinovic J, Kaplan J, Benachi A, Lacombe D, Sonigo P, Drunat S, Vekemans M, Agenor J, Encha Razavi F, Attie-Bitach T.
Birth Defects Res. 2018 Apr 17.

In utero ultrasound diagnosis of corpus callosum agenesis leading to the identification of orofaciodigital type 1 syndrome in female fetuses.

Alby C, Boutaud L, Bonniere M, Collardeau-Frachon S, Guibaud L, Lopez E, Bruel AL, Aral B, Sonigo P, Roth P, Vibert-Guigue C, Castaigne V, Carbonne B, Joye N, Faivre L, Cordier MP, Bernabe Gelot A, Clementi M, Mammi I, Vekemans M, Razavi F, Gonzales M, Thauvin-Robinet C, Attie-Bitach T.
Birth Defects Res. 2018 Mar .

Fetal MRI compared with ultrasound for the diagnosis of obstructive genital malformations.

Millischer AE, Grevent D, Rousseau V, O'Gorman N, Sonigo P, Bessieres B, Ville Y, Boddaert N, Salomon LJ.
Prenat Diagn. 2017 Nov.

Large Duplications Can Be Benign Copy Number Variants: A Case of a 3.6-Mb Xq21.33 Duplication.

Maurin ML, Arfeuille C, Sonigo P, Rondeau S, Vekemans M, Turleau C, Ville Y, Malan V.
Cytogenet Genome Res. 2017.

Vein of Galen aneurysmal malformation (VGAM) in the fetus: retrospective analysis of perinatal prognostic indicators in a two-center series of 49 cases.

Paladini D, Deloison B, Rossi A, Chalouhi GE, Gandolfo C, Sonigo P, Buratti S, Millischer AE, Tuo G, Ville Y, Pistorio A, Cama A, Salomon LJ.
Ultrasound Obstet Gynecol. 2017 .

Prenatal discovery of Joubert syndrome associated with small bowel volvulus

Auregan C; Donciu V; Millischer A-E; Khen-Dunlop N; Sonigo P; Magny J-F;
Birth Defects Res. Part A Clin. Mol. Teratol. 2015 .

Fetal brain imaging following laser surgery in twin-to-twin surgery.

Stirnemann J, Chalouhi G, Essaoui M, Bahi-Buisson N, Sonigo P, Millischer AE, Lapillonne A, Guigue V, Salomon LJ, Ville Y.
BJOG. 2016 Jun 27. .

Clinical, genetic and neuropathological findings in a series of 138 fetuses with a corpus callosum malformation.

Alby C.; Malan V.; Boutaud L.; Maragoni M. A.; Sonigo P.; Encha-Razavi F.; Attie-Bitach T.;
Birth Defects Res. Part A Clin. Mol. Teratol. 2015 .

Performance of prenatal diagnosis in esophageal atresia.

Spaggiari E, Faure G, Rousseau V, Sonigo P, Millischer-Bellaiche AE, Kermorvant-Duchemin E, Muller F, Czerkiewicz I, Ville Y, Salomon LJ.
Prenat Diagn. 2015 Sep.

Prenatal prediction of pulmonary arterial hypertension in congenital diaphragmatic hernia.

Spaggiari E, Stirnemann JJ, Sonigo P, Khen-Dunlop N, De Saint Blanquat L, Ville Y.
Ultrasound Obstet Gynecol. 2015 May.

MRI and ultrasound fusion imaging for prenatal diagnosis.

Salomon LJ, Bernard JP, Millischer AE, Sonigo P, Brunelle F, Boddaert N, Ville Y.
Am J Obstet Gynecol. 2013 Aug.

Standardized fetal anatomical examination using magnetic resonance imaging: a feasibility study.

Millischer AE, Sonigo P, Ville Y, Brunelle F, Boddaert N, Salomon LJ.
Ultrasound Obstet Gynecol. 2013 Nov.

Three-dimensional helical computed tomography in prenatal diagnosis of fetal skeletal dysplasia.

Macé G, Sonigo P, Cormier-Daire V, Aubry MC, Martinovic J, Elie C, Gonzales M, Carbonne B, Dumez Y, Le Merrer M, Brunelle F, Benachi A.
Ultrasound Obstet Gynecol. 2013 Aug.

[Prenatal symptoms and diagnosis of inherited metabolic diseases].

Brassier A, Ottolenghi C, Boddaert N, Sonigo P, Attié-Bitach T, Millischer-Bellaiche AE, Baujat G, Cormier-Daire V, Valayannopoulos V, Seta N, Piraud M, Chadefaux-Vekemans B, Vianey-Saban C, Froissart R, de Lonlay P.
Arch Pediatr. 2012 Sep.

[Fetal MRI: a revolution under way].

Millischer AE, Sonigo P, Salomon LJ.
Gynecol Obstet Fertil. 2012 Jul-Aug.

Hidden mortality of prenatally diagnosed vein of Galen aneurysmal malformation: retrospective study and review of the literature.

Deloison B, Chalouhi GE, Sonigo P, Zerah M, Millischer AE, Dumez Y, Brunelle F, Ville Y, Salomon LJ.
Ultrasound Obstet Gynecol. 2012 Dec.

The in utero natural history of a cytomegalovirus-related fetal cerebral periventricular halo.

Picone O, Sonigo P, Cordier AG, Vauloup-Fellous C, Benachi A.
Prenat Diagn. 2010 Dec.

Real-time fetal magnetic resonance imaging for the dynamic visualization of the pouch in esophageal atresia.

Salomon LJ, Sonigo P, Ou P, Ville Y, Brunelle F.
Ultrasound Obstet Gynecol. 2009 Oct.

Prenatal diagnosis of cardiac rhabdomyomas: incidence of associated cerebral lesions of tuberous sclerosis complex.

Saada J, Hadj Rabia S, Fermont L, Le Bidois J, Bernardes LS, Martinovic J, Sonigo P, Dumez Y, Bonnet D, Benachi A.
Ultrasound Obstet Gynecol. 2009 Aug.

[MRI and fetal multidetector CT in the diagnosis of fetal malformations].

Brunelle F, Sonigo P, Boddaert N, Benachi A, Dumez Y.
Bull Acad Natl Med. 2008 Nov.

Prenatal and postnatal follow-up of a fetal interhemispheric arachnoid cyst with partial corpus callosum agenesis, asymmetric ventriculomegaly and localized polymicrogyria. Case report.

Fuchs F, Moutard ML, Blin G, Sonigo P, Mandelbrot L.
Fetal Diagn Ther. 2008.

Value of prenatal magnetic resonance imaging in the prediction of postnatal outcome in fetuses with diaphragmatic hernia.

Jani J, Cannie M, Sonigo P, Robert Y, Moreno O, Benachi A, Vaast P, Gratacos E, Nicolaides KH, Deprest J.
Ultrasound Obstet Gynecol. 2008 Nov.

Comparison between ultrasound and magnetic resonance imaging in assessment of fetal cytomegalovirus infection.

Picone O, Simon I, Benachi A, Brunelle F, Sonigo P.
Prenat Diagn. 2008 Aug.

Prenatal prognosis in isolated congenital diaphragmatic hernia.

Datin-Dorriere V, Rouzies S, Taupin P, Walter-Nicolet E, Benachi A, Sonigo P, Mitanchez D.
Am J Obstet Gynecol. 2008 Jan.

Prenatal diagnosis of dumbbell neuroblastoma.

Delahaye S, Doz F, Sonigo P, Saada J, Mitanchez D, Sarnacki S, Benachi A.
Ultrasound Obstet Gynecol. 2008 Jan.

Fetal magnetic resonance imaging in the antenatal diagnosis and management of hydrocolpos.

Picone O, Laperelle J, Sonigo P, Levaillant JM, Frydman R, Senat MV.
Ultrasound Obstet Gynecol. 2007 Jul.

Molar tooth sign and superior vermian dysplasia: a radiological, clinical, and genetic study.

Romano S, Boddaert N, Desguerre I, Hubert L, Salomon R, Seidenwurm D, Bahi-Buisson N, Nabbout R, Sonigo P, Lyonnet S, Brunelle F, Munnich A, de Lonlay P.
Neuropediatrics. 2006 Feb.

Contribution of fetal MR imaging in the prenatal diagnosis of Zellweger syndrome.

Mochel F, Grébille AG, Benachi A, Martinovic J, Razavi F, Rabier D, Simon I, Boddaert N, Brunelle F, Sonigo P.
AJNR Am J Neuroradiol. 2006 Feb.

Prenatal prognosis of congenital diaphragmatic hernia using magnetic resonance imaging measurement of fetal lung volume.

Gorincour G, Bouvenot J, Mourot MG, Sonigo P, Chaumoitre K, Garel C, Guibaud L, Rypens F, Avni F, Cassart M, Maugey-Laulom B, Bourlière-Najean B, Brunelle F, Durand C, Eurin D; Groupe Radiopédiatrique de Recherche en Imagerie Foetale (GRRIF).
Ultrasound Obstet Gynecol. 2005 Dec.

Esophageal atresia diagnosed with three-dimensional ultrasonography.

Yagel S, Sonigo P, Rousseau V, Sarnacki S, Cohen S, Benachi A.
Ultrasound Obstet Gynecol. 2005 Sep.

Fetal hemangiopericytoma with an associated cerebral anomaly.

Hornoy P, Sonigo P, Fallet-Bianco C, Largiliere P, Teillac D, Gomes H, Uzan M, Brunelle F.
Ultrasound Obstet Gynecol. 2005 Jul.

Neocortical neuronal arrangement in LIS1 and DCX lissencephaly may be different.

Viot G, Sonigo P, Simon I, Simon-Bouy B, Chadeyron F, Beldjord C, Tantau J, Martinovic J, Esculpavit C, Brunelle F, Munnich A, Vekemans M, Encha-Razavi F.
Am J Med Genet A. 2004 Apr 15.

Fetal lung volume estimated by 3-dimensional ultrasonography and magnetic resonance imaging in cases with isolated congenital diaphragmatic hernia.

Ruano R, Joubin L, Sonigo P, Benachi A, Aubry MC, Thalabard JC, Brunelle F, Dumez Y, Dommergues M.
J Ultrasound Med. 2004 Mar.

Fetal CT.

Brunelle F, Sonigo P, Simon I.
Childs Nerv Syst. 2003 Aug.

Malformative intracranial cysts: diagnosis and outcome.

Pierre-Kahn A, Sonigo P.
Childs Nerv Syst. 2003 Aug.

A primal sketch of the cortex mean curvature: a morphogenesis based approach to study the variability of the folding patterns.

Cachia A, Mangin JF, Rivière D, Kherif F, Boddaert N, Andrade A, Papadopoulos-Orfanos D, Poline JB, Bloch I, Zilbovicius M, Sonigo P, Brunelle F, Régis J.
IEEE Trans Med Imaging. 2003 Jun.

Features of the developing brain.

Encha-Razavi F, Sonigo P.
Childs Nerv Syst. 2003 Aug.

Lumbosacral lipomas: in utero diagnosis and prognosis.

Pierre-Kahn A, Sonigo P.
Childs Nerv Syst. 2003 Aug.

Intellectual prognosis of the Dandy-Walker malformation in children: the importance of vermian lobulation.

Boddaert N, Klein O, Ferguson N, Sonigo P, Parisot D, Hertz-Pannier L, Baraton J, Emond S, Simon I, Chigot V, Schmit P, Pierre-Kahn A, Brunelle F.
Neuroradiology. 2003 May.

Prenatal diagnosis of a large axillary cystic lymphangioma by three-dimensional ultrasonography and magnetic resonance imaging.

Ruano R, Aubry JP, Simon I, Grebille AG, Sonigo P, Dumez Y, Dommergues M.
J Ultrasound Med. 2003 Apr.

Prenatal diagnosis of hypoplasia of the corpus callosum in association with non-ketotic hyperglycinemia.

Paupe A, Bidat L, Sonigo P, Lenclen R, Molho M, Ville Y.
Ultrasound Obstet Gynecol. 2002 Dec.

Arthrogryposis multiplex congenita and cerebellopontine ischemic lesions in sibs: recurrence of prenatal disruptive brain lesions with different patterns of expression?

Mahieu-Caputo D, Salomon LJ, Dommergues M, Aubry MC, Sonigo P, Martinovic Y, Le Merrer M, Dumez Y, Encha-Razavi F.
Fetal Diagn Ther. 2002 May-Jun.

Antenatal diagnosis of spinal lipomas.

Thorne A, Pierre-Kahn A, Sonigo P.
Childs Nerv Syst. 2001 Dec.

Determination of the anatomical location of an antenatal intestinal occlusion by magnetic resonance imaging.

Benachi A, Sonigo P, Jouannic JM, Simon I, Révillon Y, Brunelle F, Dumez Y.
Ultrasound Obstet Gynecol. 2001 Aug.

Fetal lung volume measurement by magnetic resonance imaging in congenital diaphragmatic hernia.

Mahieu-Caputo D, Sonigo P, Dommergues M, Fournet JC, Thalabard JC, Abarca C, Benachi A, Brunelle F, Dumez Y.
BJOG. 2001 Aug.

[Prenatal semiology of diastematomyelia].

Chat L, Sonigo P, Simon I, Schmit P, Brunelle F.
J Radiol. 2001 Jun.

Prenatal diagnosis and postnatal follow-up of pericallosal lipoma: report of seven new cases.

Ickowitz V, Eurin D, Rypens F, Sonigo P, Simon I, David P, Brunelle F, Avni FE.
AJNR Am J Neuroradiol. 2001 Apr.

Fetal lung volume: estimation at MR imaging-initial results.

Rypens F, Metens T, Rocourt N, Sonigo P, Brunelle F, Quere MP, Guibaud L, Maugey-Laulom B, Durand C, Avni FE, Eurin D.
Radiology. 2001 Apr.

The contribution of prenatal diagnosis to the understanding of malformative intracranial cysts: state of the art.

Pierre-Kahn A, Hanlo P, Sonigo P, Parisot D, McConnell RS.
Childs Nerv Syst. 2000 Nov.

Prenatal diagnosis of sporadic Apert syndrome: a sequential diagnostic approach combining three-dimensional computed tomography and molecular biology.

Mahieu-Caputo D, Sonigo P, Amiel J, Simon I, Aubry MC, Lemerrer M, Delezoïde AL, Gigarel N, Dommergues M, Dumez Y.
Fetal Diagn Ther. 2001 Jan-Feb.

Intracranial venous anomalies associated with atretic cephalocoeles.

Brunelle F, Baraton J, Renier D, Teillac D, Simon I, Sonigo P, Hertz-Pannier L, Emond S, Boddaert N, Chigot V, Lellouch-Tubiana A.
Pediatr Radiol. 2000 Nov.

[Contribution of MRI in the evaluation of fetal malformations].

Sonigo P.
J Gynecol Obstet Biol Reprod (Paris). 2000 May.

MR imaging of fetal cerebral anomalies.

Sonigo PC, Rypens FF, Carteret M, Delezoide AL, Brunelle FO.
Pediatr Radiol. 1998 Apr.

Prenatal MR diagnosis of a thick corpus callosum.

Rypens F, Sonigo P, Aubry MC, Delezoide AL, Cessot F, Brunelle F.
AJNR Am J Neuroradiol. 1996 Nov-Dec.

Prenatal MRI diagnosis of fetal cerebral tuberous sclerosis.

Sonigo P, Elmaleh A, Fermont L, Delezoíde AL, Mirlesse V, Brunelle F.
Pediatr Radiol. 1996.

Prenatal diagnosis of tuberous sclerosis. Use of magnetic resonance imaging and its implications for prognosis.

Werner H Jr, Mirlesse V, Jacquemard F, Sonigo P, Delezoide AL, Gonzales M, Brunelle F, Fermont L, Daffos F.
Prenat Diagn. 1994 Dec.

Congenital cystic adenomatoid malformation of the lung: prenatal management and prognosis.

Revillon Y, Jan D, Plattner V, Sonigo P, Dommergues M, Mandelbrot L, Dumez Y, Nihoul-Fékété C.
J Pediatr Surg. 1993 Aug.

[Contribution of imaging techniques in acute neonatal renal pathology].

Sonigo P, Perret C, Hubert P, Gagnadoux MF, Lallemand D.
Ann Pediatr (Paris). 1993 Feb.

Prenatal management of congenital cystic adenomatoid malformation of the lung.

Dumez Y, Mandelbrot L, Radunovic N, Révillon Y, Dommergues M, Aubry MC, Aubry JP, Narcy F, Sonigo P.
J Pediatr Surg. 1993 Jan.

Magnetic resonance imaging in antenatal diagnosis of tuberous sclerosis.

Mirlesse V, Wener H, Jacquemard F, Perotez C, Daffos F, Sonigo P, Brunelle F.
Lancet. 1992 Nov 7.

Experience and skills

Dr Pascale Sonigo
  • Creation of the prenatal diagnostic service ( fetal MRI , fetal CT ,  brain US)  within the pediatric radiology department of Necker Hospital (1989)
  • Contributed to the the defining of the MRI exploration technique in the fetal brain (in vivo)
  • Creation of a reference guide on fetal cerebral and meningeal malformations (echography, MRI and uterine content) (1992).
  • Director of the prenatal diagnostic service imaging  and liaison with the obstetric/gynecological and fetal medicine service (Prof. Yves VILLE), genetic service (Prof. MUNNICH) and fetal , neonatal and pediatric surgery  services (1989).
  • Practitioner in the Multidisciplinary Center for Prenatal Diagnostics (  fetal MRI and CT ,  echography) (1999)
  • Participation in the work of ANAES:
    - Recommended course of action upon the discovery of a prenatal cerebral ventriculomegaly - November 2003
  • - Screening for invasive Cytomegalovirus infections in the pregnant woman - Mars 2004
  • Teaching at the university level for a diploma in fetal medicine and fetal pathology
    And for: 
    - constitutional disorders of bone - Paris V- Necker
    - Postnatal neuroradiology:                             
      - Prenatal MRI
      - Fetal CT  and uterine content
  • Participation at multiple speaking engagements as well as national and international teaching assignments at radiology, fetal medicine and prenatal imaging conferences
  • Creation of the Center for Echography Mother-Child on 05/01/2005
    30 Avenue de Saxe 75007 Paris
    01 42 73 05 19
    Center dedicated to obstetric/gynecological and pediatric echography: screening and follow up
Dr Pascale Sonigo Dr Pascale Sonigo Dr Pascale Sonigo Dr Pascale Sonigo Dr Pascale Sonigo


Dr. Pascale SONIGO

Center for Echography – Mother - Child
30 avenue de Saxe 75007 PARIS

Phone: +33(0)1 42 73 05 19
Fax: +33(0)1 42 73 05 71


Pediatric Radiology and fetal imaging, Pr BODDAERT
Hôpital Necker-Enfants malades
149 rue de Sèvres 75015 PARIS

Phone: +33(0)1 44 49 51 72
Fax: +33(0)1 44 49 51 70


Dr Pascale Sonigo Dr Pascale Sonigo